Monoamine Oxidase A in Antisocial Personality Disorder and Borderline Personality Disorder

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Monoamine Oxidase A in Antisocial Personality Disorder and Borderline Personality Disorder

Purpose of Review Variation in the monoamine oxidase A (MAO-A) gene and MAO-A enzyme levels have been linked to antisocial behavior and aggression in clinical and non-clinical populations. Here, we provide an overview of the genetic, epigenetic, and neuroimaging research that has examined MAO-A structure and function in antisocial personality disorder (ASPD) and borderline personality disorder ...

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Personality Dimensions of Temperament and Character in Patients with Borderline Personality Disorder and Bipolar Disorder II

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Antisocial Personality Disorder

Antisocial personality disorder (ASPD) is the most reliably diagnosed condition among the personality disorders, yet treatment efforts are notoriously difficult. Many psychiatrists are reluctant to treat patients with ASPD because of widespread belief that such patients are always untreatable. There is increasing evidence, however, that ASPD may, in certain cases, be treatable. In this chapter,...

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Monoamine Oxidase-A Genetic Variants and Childhood Abuse Predict Impulsiveness in Borderline Personality Disorder

Objective Impulsivity is a core feature of borderline personality disorder (BPD) and antisocial personality disorder (ASPD) that likely arises from combined genetic and environmental influences. The interaction of the low activity variant of the monoamine oxidase-A (MAOA-L) gene and early childhood adversity has been shown to predict aggression in clinical and non-clinical populations. Although...

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ژورنال

عنوان ژورنال: Current Behavioral Neuroscience Reports

سال: 2017

ISSN: 2196-2979

DOI: 10.1007/s40473-017-0102-0